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. 2019 Jul 30;47(19):e114. doi: 10.1093/nar/gkz659

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© The Author(s) 2019. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 7. — Characteristics of temporal and spatial control over transduction capability of photo-switchable lentiviral vectors in vivo. (A) The recovery of Y77-T1 virus transduction capability induced by transmitted UV through mouse skin in vitro. Viral transduction capability was measured by relative luciferase reporter expression in 293T cells and KB cells (*P < 0.05, **P < 0.01, ***P < 0.001, n = 3). (B) Flowchart of the in vivo subcutaneous transplantation tumor model for evaluation of transduction capacity of the photo-switchable lentiviral vector. S.C: subcutaneous injection; I.T: intratumoral injections. (C) Bioluminescence imaging of nude mice inoculated with KB tumor cells at the right flank. T1(−) UV(−): group1, Y77 virus and no UV irradiation. T1(+) UV(−): group2, Y77-T1 virus and no UV irradiation; T1(+) UV(+): group3, Y77-T1 virus and 5 min of UV irradiation. There were six mice per group. (D) ROI analysis of the bioluminescence imaging in (C) (*P< 0.05, n = 6).