Figure 10.

Co-factors affecting NF-κB:DNA complex altering DNA structural conformation. (A) DNA repair protein OGG1 enhances the recruitment of RelA dimers to the κB sites through binding to an O⁶-methyl guanine damaged site (O⁶-MeG). Upon OGG1:O⁶-MeG binding, the κB site structure is altered favoring NF-κB binding. (B) Architectural transcription factor HMGA1 enhances the recruitment of RelA dimer to the IFNβ-κB site. The proposed model shows how HMGA1 transiently bind the DNA minor groove affecting the conformation of the DNA major groove facilitating NF-κB binding.