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NF-κB dimers. Cartoon representations of all possible NF-κB homo- and heterodimer combinations. Dimeric NF-κB proteins involved in canonical signaling are colored red with the ubiquitous p50:RelA heterodimer bolded for emphasis (29). Dimers that function in response to non-canonical (alternative) NF-κB signaling are colored in green with p52:RelB, the predominant NF-κB dimer of this pathway, darkened for emphasis (38). NF-κB dimers not observed in cells are colored in light grey (26).
