Figure 3.

Classification of different types of κB DNA sequences. Top panel, the κB DNA sequence, as defined during the late 1980s, is labeled as ‘Early Consensus.’ This consensus was ‘Broadened’ in the late 1990s after the discovery of NF-κB binding to novel sequences. The central base pair is highlighted in red. Conserved flanking residues are underlined. Variable central portion residues are boxed in black. Middle panel, κB DNA sequences can be sorted into three classes with respect to the nature of the nucleotide sequences within the central portion. The central base pair is highlighted in red. Bottom panel, two examples of NF-κB target genes display that only half consensus κB DNA (48). Nucleotides that do not match with the κB DNA consensus sequence are boxed in red.