Table 3.
Partial Correlation Coefficients for Biomarkers of Severity and Endothelial Function/Activation in 100 Severe Malaria and Moderately Severe Malaria Patients Adjusting for Disease Severity
| Glycosaminoglycans Assay | Biomarker | Correlation | P Value | Degree of Freedom |
|---|---|---|---|---|
| Syndecan-1 | HRP2 | 0.29 | .006 | 98 |
| Parasitemia | 0.24 | .002 | 94 | |
| Cell-free hemoglobin | 0.27 | .01 | 94 | |
| ICAM-1 | 0.46 | <.001 | 94 | |
| E-selectin | 0.15 | .15 | 94 | |
| Angiopoietin-2 | 0.48 | <.001 | 94 | |
| RH-PAT | −0.1 | .51 | 94 | |
| Sphingosine-1-phosphate | −0.13 | .13 | 87 | |
| Glycosaminoglycans; dimethylmethylene blue | HRP2 | 0.39 | <.001 | 93 |
| Parasitemia | 0.27 | .01 | 99 | |
| Cell-free hemoglobin | 0.23 | .04 | 99 | |
| ICAM-1 | 0.35 | <.001 | 99 | |
| E-selectin | 0.26 | .02 | 99 | |
| Angiopoietin-2 | 0.31 | .002 | 99 | |
| RH-PAT | −0.30 | .003 | 99 | |
| Sphingosine-1-phosphate | −0.21 | .08 | 93 | |
| Glycosaminoglycans; liquid chromatography-tandem mass spectrometry | HRP2 | 0.32 | .002 | 93 |
| Parasitemia | 0.31 | .002 | 99 | |
| Cell-free hemoglobin | 0.16 | .09 | 99 | |
| ICAM-1 | 0.27 | .009 | 99 | |
| E-selectin | 0.33 | .001 | 99 | |
| Angiopoietin-2 | 0.18 | .1 | 99 | |
| RH-PAT | −0.30 | .004 | 99 | |
| Sphingosine-1-phosphate | −0.32 | .008 | 93 |
Abbreviation: HRP2, plasma histidine-rich protein-2; ICAM-1, intercellular adhesion molecule 1; RH-PAT, reactive hyperemia-peripheral arterial tonometry.