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. 2019 Aug 8;47(19):e117. doi: 10.1093/nar/gkz674

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© The Author(s) 2019. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 1. — Characteristics of strain-specific CpG mutations. (A) A representation of whole-genome alignment between two strains, A and B. The CpGs present in the two strains can be represented in both coordinate systems; CpGs are either shared between strains (red), mutated (yellow or blue) or ‘lost’ due to indels that render the coordinate unmappable (rightmost yellow). (B and C) The CpG mutation rate (proportion of strain-specific CpGs relative to total CpGs) calculated in 100 kb bins, is comparable between BL6 and CAST strains, both genome-wide (B) and locally (C). (D) The CpG mutation rate across different genomic features.