Figure 3.
Model describing IL-1β signaling via ERK1/2, endometrial biomarkers and clinical consequences. The ERK1/2 MAP kinase enzyme cascade following IL-1β ligation is depicted, showing intermediates and signaling mechanisms. Arrows (←) indicate stimulatory effects, whereas ‘block’ symbols ( ⊥) represent inhibitory effects. H refers to the combination of E2, P4 and cAMP and postulated, related reproductive pathologies are noted. See text for other abbreviations. MEK1/2, mitogen-activated protein kinase kinase.