Figure 6.

SLX4IP functions in the same pathway as XPF but not as MUS81. (A–C) Proliferation of HEK293A-WT, SLX4IP-KO, XPF-KO, and other cell lines as indicated was measured using a CellTiter-Glo assay after 3 days in the presence of the indicated concentrations of mitomycin C (MMC). Data are presented as mean ± the standard error of the mean (n = 3). (D) Experiments were done as presented in A, B, and C. Proliferation of the indicated cell lines was measured using a CellTiter-Glo assay after 3 days in the presence of the indicated concentrations of camptothecin (CPT). DKO, double knockout; IC₅₀, half-maximal inhibitory concentration; KO, knockout; WT, wild type.