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. 2019 May 27;170(2):549–561. doi: 10.1093/toxsci/kfz122

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Published by Oxford University Press on behalf of the Society of Toxicology 2019.

This work is written by US Government employees and is in the public domain in the US.

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Figure 1. — Acetaminophen-induced liver injury and hepatic necrosis. A, Hematoxylin and eosin (H&E) stains in liver sections from vehicle and time course APAP-treated mice. B, Percentage of hepatic necrosis calculated from H&E images in vehicle and time course APAP-treated mice. C, Serum ALT concentration in vehicle and time course APAP-treated mice. D, Serum AST concentration in vehicle and time course APAP-treated mice. E, Hepatic GSH levels measured in vehicle and time course APAP-treated mice. *p < .05 compared with vehicle-treated mice.