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. 2019 May 27;170(2):549–561. doi: 10.1093/toxsci/kfz122

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Published by Oxford University Press on behalf of the Society of Toxicology 2019.

This work is written by US Government employees and is in the public domain in the US.

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Figure 6. — TGFβ1-induced hepatocyte cell death was reduced in APAP-treated mice by treatment with GW788388. A, Immunohistochemistry for pSMAD3 in liver sections from vehicle and 6 h APAP-treated mice injected with DMSO or GW788388. B, Relative pSMAD3 protein expression as measured by ELISA assay in vehicle and 6 h APAP-treated mice administered DMSO or GW788388. C, Immunoblot for pJNK and JNK in liver homogenates from vehicle and 6 h APAP-treated mice injected with DMSO or GW788388. D, Quantification of pJNK and JNK immunoblots in livers from vehicle and 6 h APAP-treated mice injected with DMSO or GW788388. E, TUNEL staining images in liver sections from vehicle and 6 h APAP-treated mice injected with DMSO or GW788388. F, Quantification of TUNEL staining in vehicle and 6 h APAP-treated mice injected with DMSO or GW788388 expressed in percent area. *p < .05 compared with vehicle-treated mice injected with DMSO. #p < .05 compared with 6 h APAP-treated mice injected with DMSO.