Table 2.
Association of imputed body mass index (BMI) at age 10, BMI at age 18, and current BMI with risk of epithelial ovarian cancer
| HR (95% CI) |
||||
|---|---|---|---|---|
| Cases | P-Ys | Model 1a | Model 2b | |
| Imputed BMI at age 10 | ||||
| <14.0 | 133 | 233 450 | 1.00 (Ref) | 1.00 (Ref) |
| 14.0–15.9 | 278 | 528 018 | 0.93 (0.76–1.15) | 0.93 (0.75–1.14) |
| 16.0–17.9 | 192 | 434 683 | 0.80 (0.64–1.00) | 0.78 (0.62–0.97) |
| 18.0–19.9 | 101 | 189 037 | 0.99 (0.76–1.28) | 0.93 (0.71–1.20) |
| ≥20.0 | 84 | 185 030 | 0.82 (0.62–1.08) | 0.74 (0.56–0.98) |
| Per 5 BMI units | 0.91 (0.81–1.03) | 0.84 (0.74–0.96) | ||
| P-trend | 0.14 | 0.01 | ||
| BMI at age 18 | ||||
| <20.0 | 260 | 581 454 | 0.87 (0.74–1.01) | 0.86 (0.73–1.01) |
| 20.0–24.9 | 444 | 837 416 | 1.00 (Ref) | 1.00 (Ref) |
| 25.0–29.9 | 63 | 119 249 | 0.98 (0.75–1.28) | 0.98 (0.75–1.29) |
| ≥30.0 | 21 | 32 099 | 1.32 (0.85–2.05) | 1.32 (0.84–2.08) |
| Per 5 BMI units | 1.16 (1.04–1.29) | 1.17 (1.03–1.33) | ||
| P-trend | 0.006 | 0.02 | ||
| Current BMI | ||||
| <25.0 | 381 | 841 626 | 1.00 (Ref) | 1.00 (Ref) |
| 25.0–29.9 | 230 | 429 093 | 1.02 (0.87–1.21) | 1.00 (0.85–1.18) |
| ≥30.0 | 177 | 299 499 | 1.20 (1.00–1.44) | 1.15 (0.95–1.40) |
| Per 5 BMI units | 1.09 (1.03–1.16) | 1.06 (0.99–1.14) | ||
| P-trend | 0.005 | 0.08 | ||
a
Stratified by calendar time, and adjusted for age at menarche, tubal ligation, duration of OC use, duration of premenopause, duration of postmenopause, menopausal status, type of menopause, duration of estrogen-only HT use, duration of estrogen and progesterone HT use, duration of other HT use, height, parity and smoking status.
b
Model 1 + mutually controlling for imputed BMI at age 10, BMI at age 18, and current BMI.
HR, hazard ratio; CI, confidence interval; P-Y, person-years; HT, hormone therapy.