Table 3.
Associations of imputed body mass index (BMI) at age 10, BMI change between age 10 and 18, and BMI change after age 18 with risk of epithelial ovarian cancer
| Cases | P-Ys | HR (95% CI)a | |
|---|---|---|---|
| Imputed BMI at age 10 | |||
| <14.0 | 133 | 233 450 | 1.00 (Ref) |
| 14.0–15.9 | 278 | 528 018 | 0.99 (0.80–1.23) |
| 16.0–17.9 | 192 | 434 683 | 0.91 (0.72–1.16) |
| 18.0–19.9 | 101 | 189 037 | 1.21 (0.91–1.60) |
| ≥20.0 | 84 | 185 030 | 1.16 (0.81–1.59) |
| Per 5 BMI units | 1.04 (0.91–1.20) | ||
| P-trend | 0.55 | ||
| BMI change between age 10 and 18 | |||
| <2.0 | 101 | 294 188 | 0.62 (0.48–0.81) |
| 2.0–3.9 | 191 | 371 462 | 1.00 (Ref) |
| 4.0–5.9 | 213 | 422 330 | 0.97 (0.79–1.19) |
| 6.0–7.9 | 158 | 276 497 | 1.08 (0.87–1.35) |
| ≥8.0 | 125 | 205 741 | 1.16 (0.91–1.48) |
| Per 5 BMI units | 1.24 (1.11–1.39) | ||
| P-trend | 0.0002 | ||
| BMI change since age 18 | |||
| <−2.0 | 35 | 61 374 | 1.01 (0.70–1.47) |
| −2.0 to 1.9 | 188 | 463 958 | 1.00 (Ref) |
| 2.0–3.9 | 165 | 334 053 | 1.15 (0.93–1.42) |
| ≥4.0 | 400 | 710 833 | 1.12 (0.94–1.34) |
| Per 5 BMI units | 1.06 (0.99–1.14) | ||
| P-trend | 0.10 | ||
a
Stratified by calendar time, mutually controlling for imputed BMI at age 10, BMI change between age 10 and 18 and BMI change since age 18, and adjusted for age at menarche, tubal ligation, duration of OC use, duration of premenopause, duration of postmenopause, menopausal status, type of menopause, duration of estrogen-only HT use, duration of estrogen and progesterone HT use, duration of other HT use, height, parity and smoking status.
HR, hazard ratio; CI, confidence interval; P-Y, person-years; HT, hormone therapy.