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Inhibition of TDP1 by 1 and 2. (A) Schematic representation 3′ phosphotyrosyl DNA substrate (N14Y) conversion by TDP1 into cleaved products (N14P). (B) Representative gel for inhibition of TDP1-catalized hydrolysis by 1 and 2: lane 1, N14Y only; lane 2, N14Y and TDP1; lanes 3–10 3-fold serial dilution of 1 from 10 mM to 5 μM; lanes 11–18 3-fold serial dilution of 2 from 10 mM to 5 μM.
