Figure 3.

Evolution of TMBs in index patient. (A) Acute T₂*-weighted 3 T MRI obtained within 48 h of injury shows pattern of TMBs (within yellow oval) consistent with T₂*-weighted 3 T MRI obtained 3 months post injury (B), the last MRI obtained. The patient died ∼7 months post-injury. (C) Post-mortem T₂*-weighted 7 T MRI showed TMBs remained stable from acute in vivo MRI to post-mortem MRI, with some morphology changes from brain extraction. Pattern of linear TMBs observed on post-mortem coronal (D) and axial (E) images of the whole brain. Region targeted for histopathological analysis outlined in yellow (E). (F) High-resolution small-bore 7 T MRI of targeted region to confirm TMB imaging within tissue prior to embedding region of interest for histological co-localization of TMB.