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. 2019 Jul 2;25(10):660–667. doi: 10.1093/molehr/gaz038

Figure 1.

Figure 1

PRL attenuates pro-inflammatory cytokine secretion induced by LPS in human placenta. PRL co-treatment reduces (A) TNF-α, (B) IL-1β and (C) IL-6 secretion into culture media. Since the data showed no normal distribution, they are presented as boxes and whiskers: box lines indicate 25, 50 and 75 percentiles, and whiskers indicate 5 and 95 percentiles. Outliers are indicated in closed circles. U = untreated, Vh = vehicle, PRL = prolactin 500 ng/mL unless another concentration is indicated, LPS = lipopolysaccharide 500 ng/mL. DXM = dexamethasone 300 nm, MTX = methotrexate 50 μm, Del1–9 = Del-1-9-G129R 2500 ng/mL. One-way ANOVA and Dunn post hoc test. Different letters indicate a significant difference (P < 0.05) between them. n = 8 independent experiments in triplicate.