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. 2019 Oct 30;14(10):e0224486. doi: 10.1371/journal.pone.0224486

Table 3. Hazard ratio of smoking on all-cause death, cardiac death, and non-cardiac death; univariate and multivariate analysis.

Univariate analysis Multivariate analysis
Age (years) Smoking HRa (95% CI) p-value Smoking HRa (95% CI) p-value
All-cause death Total Ex 1.29 (1.24–1.35) < .001 Ex 1.15 (1.11–1.20) < .001
Current 1.61 (1.57–1.65) < .001 Current 1.64 (1.59–1.69) < .001
40 Ex 1.25 (1.10–1.42) 0.001 Ex 0.92 (0.80–1.05) 0.216
Current 2.22 (2.06–2.39) < .001 Current 1.50 (1.37–1.64) < .001
50 Ex 1.53 (1.39–1.69) < .001 Ex 1.03 (0.93–1.14) 0.610
Current 2.78 (2.62–2.94) < .001 Current 1.70 (1.59–1.82) < .001
60 Ex 1.82 (1.70–1.95) < .001 Ex 1.24 (1.16–1.34) < .001
Current 2.53 (2.42–2.65) < .001 Current 1.65 (1.57–1.73) < .001
70 Ex 1.61 (1.51–1.72) < .001 Ex 1.19 (1.11–1.27) < .001
Current 1.96 (1.87–2.06) < .001 Current 1.43 (1.36–1.51) < .001
80 Ex 1.37 (1.15–1.64) 0.001 Ex 1.11 (0.92–1.34) 0.287
Current 1.55 (1.33–1.81) < .001 Current 1.29 (1.10–1.52) 0.002
Cardiac death Total Ex 0.98 (0.89–1.08) 0.686 Ex 1.03 (0.93–1.14) 0.552
Current 1.28 (1.21–1.35) < .001 Current 1.65 (1.55–1.77) < .001
40 Ex 1.41 (1.01–1.98) 0.043 Ex 0.91 (0.64–1.30) 0.616
Current 2.79 (2.30–3.39) < .001 Current 1.82 (1.45–2.28) < .001
50 Ex 1.25 (0.96–1.63) 0.094 Ex 0.85 (0.65–1.12) 0.225
Current 2.68 (2.32–3.10) < .001 Current 1.76 (1.48–2.08) < .001
60 Ex 1.35 (1.15–1.59) < .001 Ex 1.07 (0.90–1.27) 0.432
Current 2.14 (1.94–2.36) < .001 Current 1.65 (1.47–1.85) < .001
70 Ex 1.21 (1.05–1.39) 0.010 Ex 1.09 (0.94–1.26) 0.272
Current 1.51 (1.37–1.67) < .001 Current 1.37 (1.22–1.53) < .001
80 Ex 1.04 (0.70–1.53) 0.857 Ex 0.89 (0.59–1.35) 0.593
Current 1.06 (0.75–1.49) 0.754 Current 0.96 (0.67–1.38) 0.822
Non-cardiac death Total Ex 1.39 (1.33–1.45) < .001 Ex 1.18 (1.13–1.24) < .001
Current 1.70 (1.66–1.75) < .001 Current 1.63 (1.58–1.68) < .001
40 Ex 1.23 (1.07–1.41) 0.004 Ex 0.92 (0.79–1.07) 0.264
Current 2.13 (1.97–2.31) < .001 Current 1.45 (1.31–1.59) < .001
50 Ex 1.59 (1.43–1.76) < .001 Ex 1.06 (0.95–1.19) 0.291
Current 2.80 (2.63–2.98) < .001 Current 1.69 (1.57–1.82) < .001
60 Ex 1.95 (1.81–2.10) < .001 Ex 1.29 (1.19–1.39) < .001
Current 2.64 (2.52–2.77) < .001 Current 1.65 (1.56–1.74) < .001
70 Ex 1.77 (1.64–1.91) < .001 Ex 1.22 (1.12–1.32) < .001
Current 2.14 (2.02–2.26) < .001 Current 1.44 (1.36–1.53) < .001
80 Ex 1.50 (1.23–1.84) < .001 Ex 1.18 (0.95–1.46) 0.127
Current 1.74 (1.46–2.06) < .001 Current 1.40 (1.17–1.69) < .001

HR; hazard ratio, CI; confidence interval, Ex; ex-smoker, current; current smoker

a Hazard ratio of various outcomes according to smoking status compared to never smoker.