Table 3. Hazard ratio of smoking on all-cause death, cardiac death, and non-cardiac death; univariate and multivariate analysis.
Univariate analysis | Multivariate analysis | ||||||
---|---|---|---|---|---|---|---|
Age (years) | Smoking | HRa (95% CI) | p-value | Smoking | HRa (95% CI) | p-value | |
All-cause death | Total | Ex | 1.29 (1.24–1.35) | < .001 | Ex | 1.15 (1.11–1.20) | < .001 |
Current | 1.61 (1.57–1.65) | < .001 | Current | 1.64 (1.59–1.69) | < .001 | ||
40 | Ex | 1.25 (1.10–1.42) | 0.001 | Ex | 0.92 (0.80–1.05) | 0.216 | |
Current | 2.22 (2.06–2.39) | < .001 | Current | 1.50 (1.37–1.64) | < .001 | ||
50 | Ex | 1.53 (1.39–1.69) | < .001 | Ex | 1.03 (0.93–1.14) | 0.610 | |
Current | 2.78 (2.62–2.94) | < .001 | Current | 1.70 (1.59–1.82) | < .001 | ||
60 | Ex | 1.82 (1.70–1.95) | < .001 | Ex | 1.24 (1.16–1.34) | < .001 | |
Current | 2.53 (2.42–2.65) | < .001 | Current | 1.65 (1.57–1.73) | < .001 | ||
70 | Ex | 1.61 (1.51–1.72) | < .001 | Ex | 1.19 (1.11–1.27) | < .001 | |
Current | 1.96 (1.87–2.06) | < .001 | Current | 1.43 (1.36–1.51) | < .001 | ||
80 | Ex | 1.37 (1.15–1.64) | 0.001 | Ex | 1.11 (0.92–1.34) | 0.287 | |
Current | 1.55 (1.33–1.81) | < .001 | Current | 1.29 (1.10–1.52) | 0.002 | ||
Cardiac death | Total | Ex | 0.98 (0.89–1.08) | 0.686 | Ex | 1.03 (0.93–1.14) | 0.552 |
Current | 1.28 (1.21–1.35) | < .001 | Current | 1.65 (1.55–1.77) | < .001 | ||
40 | Ex | 1.41 (1.01–1.98) | 0.043 | Ex | 0.91 (0.64–1.30) | 0.616 | |
Current | 2.79 (2.30–3.39) | < .001 | Current | 1.82 (1.45–2.28) | < .001 | ||
50 | Ex | 1.25 (0.96–1.63) | 0.094 | Ex | 0.85 (0.65–1.12) | 0.225 | |
Current | 2.68 (2.32–3.10) | < .001 | Current | 1.76 (1.48–2.08) | < .001 | ||
60 | Ex | 1.35 (1.15–1.59) | < .001 | Ex | 1.07 (0.90–1.27) | 0.432 | |
Current | 2.14 (1.94–2.36) | < .001 | Current | 1.65 (1.47–1.85) | < .001 | ||
70 | Ex | 1.21 (1.05–1.39) | 0.010 | Ex | 1.09 (0.94–1.26) | 0.272 | |
Current | 1.51 (1.37–1.67) | < .001 | Current | 1.37 (1.22–1.53) | < .001 | ||
80 | Ex | 1.04 (0.70–1.53) | 0.857 | Ex | 0.89 (0.59–1.35) | 0.593 | |
Current | 1.06 (0.75–1.49) | 0.754 | Current | 0.96 (0.67–1.38) | 0.822 | ||
Non-cardiac death | Total | Ex | 1.39 (1.33–1.45) | < .001 | Ex | 1.18 (1.13–1.24) | < .001 |
Current | 1.70 (1.66–1.75) | < .001 | Current | 1.63 (1.58–1.68) | < .001 | ||
40 | Ex | 1.23 (1.07–1.41) | 0.004 | Ex | 0.92 (0.79–1.07) | 0.264 | |
Current | 2.13 (1.97–2.31) | < .001 | Current | 1.45 (1.31–1.59) | < .001 | ||
50 | Ex | 1.59 (1.43–1.76) | < .001 | Ex | 1.06 (0.95–1.19) | 0.291 | |
Current | 2.80 (2.63–2.98) | < .001 | Current | 1.69 (1.57–1.82) | < .001 | ||
60 | Ex | 1.95 (1.81–2.10) | < .001 | Ex | 1.29 (1.19–1.39) | < .001 | |
Current | 2.64 (2.52–2.77) | < .001 | Current | 1.65 (1.56–1.74) | < .001 | ||
70 | Ex | 1.77 (1.64–1.91) | < .001 | Ex | 1.22 (1.12–1.32) | < .001 | |
Current | 2.14 (2.02–2.26) | < .001 | Current | 1.44 (1.36–1.53) | < .001 | ||
80 | Ex | 1.50 (1.23–1.84) | < .001 | Ex | 1.18 (0.95–1.46) | 0.127 | |
Current | 1.74 (1.46–2.06) | < .001 | Current | 1.40 (1.17–1.69) | < .001 |
HR; hazard ratio, CI; confidence interval, Ex; ex-smoker, current; current smoker
a Hazard ratio of various outcomes according to smoking status compared to never smoker.