Figure 11. The proposed method detects cross-frequency coupling in an in vivo human recording.

(A,B) Voltage recording (A) and spectrogram (B) from one MEA electrode over the course of a seizure; PAC and AAC were computed for the time segment outlined in red. (C) The 10 s voltage trace (blue) corresponding to the outlined segment in (A), and ${\displaystyle V_{\text{low}}}$ (red), ${\displaystyle V_{\text{high}}}$ (yellow), and ${\displaystyle A_{\text{low}}}$ (purple). (D) A 2 s subinterval of the voltage trace (blue), ${\displaystyle V_{\text{low}}}$ (red), ${\displaystyle V_{\mathrm{h}\mathrm{i}\mathrm{g}\mathrm{h}}}$ (yellow), ${\displaystyle A_{\mathrm{l}\mathrm{o}\mathrm{w}}}$ (purple), and ${\displaystyle {\varphi }_{\mathrm{l}\mathrm{o}\mathrm{w}}}$ (green). (E) ${\displaystyle A_{\mathrm{l}\mathrm{o}\mathrm{w}}}$ (purple) and ${\displaystyle A_{\mathrm{h}\mathrm{i}\mathrm{g}\mathrm{h}}}$ (red) for the 10 s segment in (C), normalized and smoothed.