Fig. 1.

Illustration to reflect the balance between physiologic outputs of a neural unit (i.e., neuronal firing “activity”) and the social influence on the component unit (“connectivity”). If neuronal firing is excessive, the balance tilts, leading to engagement of homeostatic mechanisms that reduce the connectivity and restore the balance. Conversely, if synaptic strength/number (connectivity) is reduced, this triggers a compensatory increase in neuronal firing. This neural system stabilization helps to maintain topological homeostasis, likely characterized by a narrow range of “tuned states” of the brain connectome.