TABLE 6.

Kinetic parameters derived from modeling the plasma d₃- and d₆-α-T enrichment percentages following oral d₃- and the IV d₆-α-T administration¹

Parameter	40% fat	0% fat	40% compared with 0% fat, P value	0% fat	0% fat-fast	0% fat compared with 0% fat-fast, P value
k1 (shared)2	0.797 ± 0.085	0.775 ± 0.094	0.8616	0.732 ± 0.089	0.797 ± 0.069	0.4009
k2 (shared)	0.016 ± 0.001	0.017 ± 0.001	0.4481	0.017 ± 0.001	0.016 ± 0.001	0.5347
Half-life (shared), h	42.8 ± 1.7	41.8 ± 3.3	0.7421	41.5 ± 2.3	43.0 ± 2.0	0.5486
Pulse duration (d3-α-T), h	4.9 ± 1.0	4.2 ± 0.8	0.4622	4.2 ± 0.7	15.4 ± 0.8	<0.0001*
Pulse duration (d6-α-T), h	0.04 ± 0.01	0.03 ± 0.00	0.6891	0.04 ± 0.00	0.03 ± 0.00	0.5098
Delay (d3-α-T), h	1.8 ± 0.4	2.8 ± 0.4	0.0786	2.7 ± 0.4	2.5 ± 0.6	0.7411
d3-α-T fractional absorption3	63 ± 6	73 ± 3	0.1351	74 ± 3	68 ± 3	0.0392*

¹Kinetic parameters (mean ± SEM) are from the model shown in Figure 7. Individual values and for a representative subject fitted graphs are provided in the Supplemental Table 2 and Supplemental Figure 2. Model parameters were compared within subjects using a paired t-test (mean ± SEM; P values are shown; for 40% compared with 0% fat, n = 7; for 0% compared with 0% fat-fast, n = 7). *Statistically significant values.

²k₁ (from liver to plasma) and k₂ (leaving plasma) rates are set to be shared between d₃- and d₆-α-T, respectively; plasma volume is estimated for subjects in 40% fat intervention (2.71 ± 0.09 L, mean ± SEM) compared with 0% fat intervention (2.71 ± 0.10 L); 0% fat intervention (2.71 ± 0.20 L) compared with 0% fat-fast intervention (2.79 ± 0.10 L); plasma volume = 0.04167 times body weight (kg); weights were measured at the start of each intervention.

³d₃-α-T fractional absorption is corrected for the recovery of d₆-α-T.