TABLE 7.
Paired subjects (n = 6) | |||
---|---|---|---|
Characteristic | 40% fat | 0% fat | P value |
d0-γ-T | 33 ± 7 | 42 ± 14 | 0.4125 |
d0-α-T | 22 ± 4 | 17 ± 3 | 0.3844 |
d3-α-T | 9.9 ± 1.9 | 8.8 ± 1.2 | 0.6589 |
d6-α-T | 0.59 ± 0.20 | 0.66 ± 0.09 | 0.7504 |
Percent dose d3-α-T excreted2 | 33% ± 6% | 29% ± 4% | 0.6568 |
d3-α-T fractional absorption3 | 67% ± 6% | 71% ± 4% | 0.6568 |
Percent dose d6-α-T excreted4 | 2.0% ± 0.6% | 2.2% ± 0.3% | 0.7516 |
The excreted quantity (mg per 96 h; mean ± SEM) of d0-γ-T, d0-, d3-, and d6-α-T. Fecal data were compared within subjects using a paired t-test (mean ± SEM; P values are shown for 40% compared with 0% fat, n = 6, subjects 1–5, 8). Molecular weights for d0-γT = 417, d0-α-T = 430, d3-α-T = 433, and d6-α-T = 436 g/mol.
Percent dose d3-α-T excreted = mg d3-α-T excreted/30 mg × 100.
d3-α-T fractional absorption = 100% – percent dose d3-α-T excreted.
Percent dose d6-α-T excreted = mg d6-α-T excreted/30 mg × 100.