Skip to main content
. Author manuscript; available in PMC: 2020 Jun 26.
Published in final edited form as: Nephron. 2019 Jun 26;143(3):158–161. doi: 10.1159/000501278

Figure 1: Panx1 and ATP contribute to inflammation:

Figure 1:

Panx1 and ATP play central roles in the inflammatory pathway. During injury, activation of Panx1 channel causes efflux of extracellular ATP, which activates the purinergic P2X and P2Y signaling pathway and initiates inflammation. Extracellular ATP can also be cleaved by CD39 to from ADP, AMP, which is then converted into adenosine by CD73. Adenosine binds with to A2A adenosine receptors that leads to an anti-inflammatory effect. Cytoplasmic calcium influx due to purinergic signaling can alter mitochondrial function. Intracellular ATP is necessary for maintenance of mitochondrial function, autophagy and cell survival. Activation of Panx1 channel causes reduced intracellular ATP pool which negatively affects cell survival. Panx1 channel in endoplasmic reticulum acts as leaky calcium channel and aids in intracellular calcium influx.