TABLE 1.
DNA Aptamer | Sequence (5’ → 3’) |
Capture Aptamer (25cF) | 5’-ATACGGGAGCCAACACCA-CCTCTCACATTATATTGTG AATACTTCGTGCTGTTT-AGAGCAGGTGTGACGGAT-3’ |
Reporter Aptamer (2F) | 5’-ATACGGGAGCCAACACCA-CGTTGCGCAGCTGGGGGC AGTGCTCTTTCGATTTGG-AGAGCAGGTGTGACGGAT-3’ |
Target Peptide | Amino Acid Sequence |
BNP (32 amino acids) | Ser-Pro-Lys-Met-Val-Gln-Gly-Ser-Gly-Cys-Phe-Gly-Arg-Lys-Met-Asp-Arg-Ile-Ser-Ser-Ser-Ser-Gly-Leu-Gly-Cys-Lys-Val-Leu-Arg-Arg-His |
Notes: Eighteen base constant sequence PCR primer ends built into the aptamers are in bolded.