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Damage to placental structures could result from direct action of P gingivalis virulence factors (A), proinflammatory cells responding to P gingivalis (B1), proinflammatory cells responding to the altered placental microbiome (B2), systemic spread of proinflammatory mediators responding to a dysbiotic oral microbiome (C), or damage to the placental structure may then lead to various APOs.
APO, adverse pregnancy outcome.
