Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 May 10;104(11):2215–2224. doi: 10.3324/haematol.2018.205351

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright© 2019 Ferrata Storti Foundation

Material published in Haematologica is covered by copyright. All rights are reserved to the Ferrata Storti Foundation. Use of published material is allowed under the following terms and conditions:

https://creativecommons.org/licenses/by-nc/4.0/legalcode. Copies of published material are allowed for personal or internal use. Sharing published material for non-commercial purposes is subject to the following conditions:

https://creativecommons.org/licenses/by-nc/4.0/legalcode, sect. 3. Reproducing and sharing published material for commercial purposes is not allowed without permission in writing from the publisher.

PMC Copyright notice

Figure 1. — Aml1-ETO ameliorates the key features of the myeloproliferative neoplasm phenotype caused by K-RasG12D. (A) Schematic representation of in vivo competitive transplant experiment. (B-I) Analysis of recipients of Mx1-Cre^tg/+ controls; CON (n=13), Aml1^ETO/+;Mx1-Cre^tg/+; AM (n=14), Kras^G12D/+;Mx1-Cre^tg/+; KM (n=12) and Aml1^ETO/+;Kras^G12D/+;Mx1-Cre^tg/+; AKM fetal liver (FL) (n=14) for (B) peripheral blood (PB) white blood cell (WBC) count. (C) PB hemoglobin levels. (D) Bone marrow (BM) cellularity per tibia and femur. (E and F) CD45.2 Mac1⁺Gr1^lo myeloid cells as absolute number in the PB (E) and spleen (F). (G) Representative FACS plots of Mac1⁺Gr1⁺ and Mac1⁺Gr1^lo myeloid cells as a percentage of LiveCD19⁻CD4⁻CD8a⁻NK1.1⁻CD45.2⁺ cells across all experiments in the PB. (H) Spleen weight. (I) Platelet count. Results were generated in three independent experiments. The results were analyzed using multiple comparison ANOVA and are presented as mean±Standard Deviation. ^*P<0.05; ^**P<0.01; ^***P<0.001; ^****P<0.0001.