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. 2019 Oct 24;13:90. doi: 10.3389/fnana.2019.00090

FIGURE 4.

FIGURE 4

Environmental enrichment accelerates the increase in BDNF protein levels in early postnatal striatum. BDNF protein concentrations (ng/ml) for individual standard (SE; grey), and enriched (EE; cyan) housed mice at ages P8 (n = 5), P10 (n = 8), and P15 (n = 8). Dark blue brackets and asterisks (EE Samples): EE samples exhibited significantly higher concentrations of BDNF at P10 and P15 compared to P8 levels (P10: p = 0.002; P15: p = 0.001). Light blue bracket and asterisks (SE Samples): SE material only yielded differences between P8 and P15 (p = 0.001). Red bar and asterisks (Housing): Pairwise comparisons revealed a significantly greater level of BDNF protein present in the striatum of EE vs. SE mice at P10 (p = 0.036; black asterisk). Means (solid bar) and standard errors of the mean (s.e.m.; extent of white boxes) are depicted. ∗p < 0.05; ∗∗p < 0.01.