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. 2019 Oct 24;13:1138. doi: 10.3389/fnins.2019.01138

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Copyright © 2019 Qi, Yu, Fu, Liu, Gao, Tu, Kang, Shi, Li, Li and Kang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) Experimental Design. Adult male SD rats were preselected to be able to run in a small-animal treadmill before the start of the experiment. After 1 week of selecting, the rats were allocated to kept Sed or ExT. All rats were implanted with the bilateral PVN cannulae, and then were allowed to recover for a week. 2K1C or SHAM surgeries were carried out at week zero. Then the ExT groups were put on a treadmill and let run at an initial speed of 5.0 m/min, and the speed was gradually increased to 16 m/min in the second week and kept through the end of exercise. (B) ExT or PVN infusion of TAK242 lowered blood pressure of 2K1C hypertensive rats. ExT reduced SBP in 2K1C + ExT + vehicle in comparison with 2K1C + Sed + vehicle rats from week six till the end of the study. PVN infusion of TAK242 in the 2K1C + Sed + TAK242 rats also reduced SBP in comparing with 2K1C + Sed + vehicle group. ^∗P < 0.05 versus SHAM rats (SHAM + Sed + PVN vehicle, SHAM + ExT + PVN vehicle or SHAM + Sed + PVN TAK242). ^†P < 0.05 (2K1C + ExT + PVN vehicle or 2K1C + Sed + PVN TAK242) versus 2K1C + Sed + PVN vehicle. ΔP < 0.05 2K1C + Sed + PVN TAK242 versus 2K1C + ExT + PVN vehicle.