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The schematic showing the mechanism by which exercise training attenuates hypertension. 2K1C induced hypertension increases TLR4/MyD88/NF-κB signaling in the PVN, which results in the overloads of PICs, causes sympathoexcitation and eventually accelerate the progression of hypertension. ExT can reverses this pathophysiological process of hypertension by attenuating TLR4/MyD88/NF-κB signaling in the PVN.
