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. 2019 Oct 24;13:1138. doi: 10.3389/fnins.2019.01138

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Copyright © 2019 Qi, Yu, Fu, Liu, Gao, Tu, Kang, Shi, Li, Li and Kang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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ExT or PVN infusion of TAK242 attenuated PVN levels of TLR4 and MyD88 mRNA and protein expression of 2K1C hypertensive rats. (A) Immunoreactive bands of TLR4, MyD88 and β-actin in the PVN. (B) Statistic of TLR4 and MyD88 protein expression. (C,D) Statistic of TLR4 and MyD88 mRNA levels. ^∗P < 0.05 versus SHAM rats (SHAM + Sed + PVN vehicle, SHAM + ExT + PVN vehicle or SHAM + Sed + PVN TAK242). ^†P < 0.05 (2K1C + ExT + PVN vehicle or 2K1C + Sed + PVN TAK242) versus 2K1C + Sed + PVN vehicle.