Table 3.

Risk of creatinine doubling, dialysis initiation, and all-cause mortality with sodium bicarbonate treatment

	Hazard ratio	95% confidence interval	p value
Creatinine doubling (number of events N = 87)
Unadjusted	0.36	0.22–0.58	< 0.001
Model 1	0.36	0.22–0.57	< 0.001
Model 2	0.36	0.22–0.58	< 0.001
Model 3	0.36	0.22–0.57	< 0.001
Model 4	0.36	0.23–0.59	< 0.001
Dialysis initiation (number of events N = 71)
Unadjusted	0.5	0.31–0.81	0.005
Model 1	0.5	0.31–0.81	0.005
Model 2	0.49	0.30–0.80	0.004
Model 3	0.34	0.20–0.56	< 0.001
Model 4	0.28	0.16–0.48	< 0.001
All-cause mortality (number of events N = 37)
Unadjusted	0.43	0.22–0.87	0.01
Model 1	0.43	0.21–0.86	0.018
Model 2	0.42	0.21–0.85	0.015
Model 3	0.38	0.18–0.77	0.007
Model 4	0.36	0.18–0.74	0.005

Model 1 adjusted for age and sex; model 2 adjusted for model 1 and demographics, body mass index, and blood pressure. Model 3: adjusted for model 2 and comorbidities (renal function. cardiovascular disease, peripheral arterial disease, diabetes, hypertension). Model 4: adjusted for model 3 and proteinuria, use of renin–angiotensin–aldosterone system inhibitors