Table 6.
Safety endpoints according to study allocation
| Sodium bicarbonate | Standard care | ||||
|---|---|---|---|---|---|
| Baseline | Follow-up | p value | Baseline | Follow up | |
| Mean systolic blood pressure mmHg (SD) | 129 (19) | 127 (16) | 0.147 | 128 (18) | 127 (15) |
| Mean systolic blood pressure change mmHg | − 1.5 (19.8) | − 1.2 (10.9) | |||
| Mean diastolic blood pressure mmHg (SD) | 73 (8) | 74 (9) | 0.202 | 74 (11) | 76 (10) |
| Mean diastolic blood pressure change mmHg | − 3.0 (11.0) | − 2.5 (10.1) | |||
| Prevalence of systolic blood pressure N (%) | |||||
| > 145 mmHg | 53 (23.3) | 36 (11.0) | 0.001 | 86 (25.7) | 52 (15.6) |
| 135–145 mmHg | 51 (15.6) | 49 (15.0) | 0.916 | 34 (10.2) | 61 (18.3) |
| < 100 mmHg | 32 (9.8) | 19 (5.8) | 0.077 | 17 (5.1) | 11 (3.3) |
| Prevalence of diastolic blood pressure N (%) | |||||
| > 85 mmHg | 28 (8.6) | 25 (7.6) | 0.743 | 10 (3.0) | 8 (2.4) |
| Serum albumin (g/dl) | 3.8 (0.4) | 3.9 (0.4) | 0.005 | 3.8 (0.4) | 3.8 (0.5) |
| Serum hemoglobin (g/dl) | 12.2 (1.8) | 12.4 (2.1) | 0.499 | 12.4 (1.7) | 12.3 (1.8) |
| Serum potassium (mmol/l) | 4.9 (0.5) | 4.9 (0.6) | 0.518 | 4.9 (0.6) | 4.9 (0.7) |
| 24 h urine sodium (mmol/l) | 157 (41) | 154 (23) | 0.384 | 173 (44) | 159 (41) |
| 24 h chloride (mmol/l) | 128 (22) | 98 (21) | 0.001 | 124 (20) | 119 (24) |
| Body weight (kg) | 74.7 (13.0) | 74.0 (11.7) | 0.467 | 75.6 (9.7) | 74.9 (11.7) |
The mean (standard deviation) of baseline as well as the last available data at follow-up is reported. Complete cases are reported and no missing data imputation is performed