Skip to main content
. 2019 Oct 24;10:1269. doi: 10.3389/fphys.2019.01269

FIGURE 10.

FIGURE 10

Mitochondrial complex II is reduced in the hippocampus of SHRSP/FAD rats and mitochondrial complex I is reduced in FAD rats. We measured mitochondrial complexes I-IV from hippocampal tissue by western blot and MANOVA was performed on the relative optical densities of protein bands from complexes I (log transformation), and II-IV. Results showed no sex effects, but a significant main FAD effect (p = 0.025) and the univariate test showed significant FAD main effects for Complexes I and II (p < 0.0001 and p < 0.039, respectively), but not III and IV. Although complex I proteins were significantly reduced in SHRSP/FAD (p < 0.01) and FAD (p < 0.01) rats, compared to WKY, complex II levels, were significantly reduced more than threefold in SHRSP/FAD rats, compared to WKY (p < 0.05). Data represent means ± SEM. p < 0.05, ∗∗p < 0.01; MANOVA with Wilks λ test and LSD Fisher’s post hoc test.