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. 2019 Oct 30;9:15627. doi: 10.1038/s41598-019-52058-z

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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The influence of haloperidol on ouabain-induced hyperactivity, stereotyped movements, and anxiety in mice. Locomotor activity and stereotypic behavior of mice under combined or separate administration of ouabain (ICV, 50 µM, 0.5 µl bilaterally) and haloperidol (intraperitoneal, 70 µg/kg, 30 min prior to the ICV injection) in the open field test was assessed by total distance walked (a), alternations index (b), and percent of time spent in the center of the open field (c) respectively during a 20-min open field test. Results are presented as mean ± SEM, N = 8 per group; *p < 0.05, **p < 0.01, ***p < 0.001 according to two-way ANOVA with Tukey’s multiple comparisons test.