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. 2019 Oct 30;9:15627. doi: 10.1038/s41598-019-52058-z

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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(a) Representative traces (top) with their respective false color plots (middle) and voltammograms (bottom) of electrically-evoked DA in the mouse dorsolateral striatum taken before (left) and 20 min after (right) ouabain (50 μM) perfusion. These signals had oxidation and reduction peaks at +0.6 V and −0.2 V, respectively, identifying the measured species as DA. The false color plots depict the voltammetric data, with time on the x-axis, applied scan potential on the y-axis, and background-subtracted faradaic current shown on the z-axis in pseudo-color. The red triangle indicates an electrical stimulation. Twenty minutes after administration, ouabain did not have a significant effect on DA release per stimulus pulse at any concentration (b) but did significantly reduce DA uptake (c), measured as the V_max, at the highest concentration (50 μM) but not lower concentrations (0.5 μM and 5 μM). Data are presented as means ± SEM of 5 mice. **p < 0.01.