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. 2019 Oct 30;9:15601. doi: 10.1038/s41598-019-51648-1

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Histopathological assessment using haematoxylin and eosin (H&E), periodic acid-Schiff (PAS), and Mason’s trichrome (MT) staining (×200) (A), quantitative fibrosis area assessed using MT staining (B), and hydroxyproline level (C) among groups. Fibrosis was more predominantly observed in peribronchial and perivascular area compared that in lung parenchymal lesion in MT staining (×400) (D). One-way ANOVA followed by a post-hoc Bonferroni test was used in Fig. 4B,C. HFD, high-fat diet; EMP, empagliflozin; DUL, dulaglutide; combi, co-treatment with EMP and DUL.