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. 2019 Oct 30;9:15642. doi: 10.1038/s41598-019-52194-6

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Calmodulin and CaMKII are not involved in the activity-dependent Ca_v3.3 current inhibition. (A–D) Examples of Ca_v3.3 currents elicited by the 1 Hz stimulation protocol during 40 s for the 1^st and the 3^rd stimulation in cells dialyzed with 100 µM CaMKII peptide (A), in cells expressing CaM₁₂₃₄ (B), in cells dialyzed with 100 µM autocamtide-2-related inhibitory peptide, AIP (C), and in cells treated for 2 hours with 1 µM STO-609 (D). (E) Amplitude of the Ca_v3.3 current at the beginning (1 s) and after 40 s obtained during the 1^st and the 3^rd stimulation normalized to the initial current amplitude obtained at the beginning of the 1^st stimulation I (1 s 1^st). Asterisks indicate significant difference in the current amplitude, as compared to the initial current amplitude. In addition, the current inhibition (red bars) and recovery (blue bars), as function of the treatment, was statistically compared to the respective control condition, as indicated. The number of cells tested is indicated into brackets. (n.s.: non-significant).