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. 2019 Oct 30;9:15642. doi: 10.1038/s41598-019-52194-6

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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The native T-type current from neurons of rat central medial (CeM) nucleus is regulated by an interplay between a rise in intracellular calcium and a phosphorylation mechanism. (A) Typical T-type current elicited by stimulation at −30 mV applied at a frequency of 1 Hz from a holding potential of −90 mV obtained from CeM neurons dialyzed with either AMP-PCP or AMP-PCP combined with BAPTA. (B) Normalized current amplitude from 1 to 40 s. (C) Average normalized current amplitude recorded at 1 s and at 40 s. Asterisks indicate significant difference in the current amplitude at 40 s as compared to the current amplitude at 1 s. The hash signs indicate statistical difference between AMP-PCP and AMP-PCP + BAPTA. (D) Representative T-type current recorded at −50 mV from holding potentials ranging from −120 to −50 mV (5 mV increment, 3.6 s duration). CeM neurons were dialyzed with either ATP (control condition) or AMP-PCP. The red trace indicates the half-inactivation potential. (E) Average steady-state inactivation curves obtained from experiments presented in (D) for neurons dialyzed with ATP (control), AMP-PCP, AMP-PCP combined with BAPTA, and in absence of ATP (ATP-free).