Table 2.
Effects of polymorphisms in the dopamine transporter 1 gene on the maximal response to 125 mg MDMA (mean ± SD (N) and statistics) corrected with MDMA AUC6 (exclusive plasma concentrations).
| DAT1 3’-UTR rs28363170 | 99 | 910 | 1010 | F | p value | p valuea | η2 |
|---|---|---|---|---|---|---|---|
| N | 8 | 56 | 79 | ||||
| Female, N [%] | 2 [25] | 29 [52] | 41 [52] | ||||
| Drug experience, N [%] | 4 [50] | 18 [32] | 31 [39] | ||||
| MDMA plasma concentration Cmax, ng/ml | 221 ± 44 (8) | 227 ± 46 (56) | 230 ± 50 (79) | 0.14 | NS | NS | 0.002 |
| MDMA plasma concentration AUC6, ng*h/ml | 939 ± 183 (8) | 958 ± 180 (56) | 961 ± 214 (79) | 0.04 | NS | NS | 0.001 |
| Visual Analog Scale rating ΔEmax | |||||||
| Any drug effect | 78 ± 20 (8) | 73 ± 26 (56) | 71 ± 28 (79) | 0.48 | NS | NS | 0.006 |
| Good drug effect | 84 ± 21 (8) | 73 ± 28 (56) | 71 ± 30 (79) | 0.97 | NS | NS | 0.013 |
| Bad drug effect | 11 ± 21 (8) | 15 ± 29 (56) | 16 ± 22 (79) | 0.14 | NS | NS | 0.002 |
| Drug liking | 83 ± 22 (8) | 77 ± 26 (56) | 70 ± 31 (79) | 1.26 | NS | NS | 0.017 |
| Stimulated | 63 ± 35 (8) | 60 ± 35 (56) | 63 ± 35 (79) | 0.09 | NS | NS | 0.001 |
| High mood | 79 ± 32 (8) | 68 ± 34 (56) | 67 ± 33 (79) | 0.57 | NS | NS | 0.008 |
| Concentration | 14 ± 22 (8) | 7.3 ± 16 (56) | 9.3 ± 16 (79) | 0.76 | NS | NS | 0.011 |
| Talkative | 23 ± 16 (8) | 19 ± 18 (56) | 22 ± 19 (79) | 0.56 | NS | NS | 0.008 |
| Appetite | -20 ± 25 (7) | -2.6 ± 37 (28) | -7 ± 26 (35) | 1.14 | NS | NS | 0.032 |
| Tired | 6.9 ± 37 (7) | 17 ± 31 (44) | 25 ± 33 (53) | 1.38 | NS | NS | 0.026 |
| Fear | 6.3 ± 21 (7) | 4.1 ± 9.5 (33) | 8 ± 19 (55) | 0.59 | NS | NS | 0.013 |
| Happy | 15 ± 16 (3) | 27 ± 20 (40) | 27 ± 18 (59) | 0.37 | NS | NS | 0.007 |
| Want to be hugged | 0 (1) | 16 ± 20 (28) | 10 ± 16 (44) | 1.16 | NS | NS | 0.030 |
| Want to hug | 0 (1) | 16 ± 19 (28) | 11 ± 16 (44) | 1.01 | NS | NS | 0.027 |
| Vital signs parameters ΔEmax | |||||||
| Systolic blood pressure, mmHg | 27 ± 15 (8) | 25 ± 11 (56) | 22 ± 14 (79) | 1.06 | NS | NS | 0.014 |
| Diastolic blood pressure, mmHg | 21 ± 18 (8) | 14 ± 8 (56) | 12 ± 9 (79) | 3.84 | 0.024* | NS | 0.049 |
| Mean arterial pressure, mmHg | 25 ± 14 (8) | 18 ± 8 (56) | 16 ± 10 (79) | 3.79 | 0.025* | NS | 0.048 |
| Heat rate beat/min | 16 ± 8 (8) | 18 ± 15 (56) | 16 ± 15 (79) | 0.28 | NS | NS | 0.004 |
| Rate pressure product, mmHg/min | 4,623 ± 2,214 (8) | 4,684 ± 2,835 (56) | 4,194 ± 2,970 (79) | 0.54 | NS | NS | 0.007 |
| Body temperature, °C | 0 ± 0.3 (8) | 0.3 ± 0.5 (56) | 0.2 ± 0.5 (79) | 1.34 | NS | NS | 0.019 |
| Adjective Mood Rating Scale rating ΔEmax | |||||||
| Activity | 4.0 ± 5.2 (8) | 2.0 ± 4.9 (56) | 2.3 ± 5.2 (79) | 0.53 | NS | NS | 0.008 |
| High mood | 2.6 ± 1.5 (8) | 3.0 ± 3.2 (56) | 2.7 ± 3.3 (79) | 0.16 | NS | NS | 0.002 |
| Fear/depression | 0.5 ± 2 (8) | 1.5 ± 3.6 (56) | 1 ± 3 (79) | 0.64 | NS | NS | 0.009 |
| DAT1 Intron 8 rs3836790 | 55 | 56 | 66 | F | p value | p value a | η 2 |
| DAT1 rs6347 | CC | CT | TT | F | p value | p valuea | η2 |
| N | 7 | 54 | 85 | ||||
| Female, N [%] | 3 [43] | 25 [46] | 46 [54] | ||||
| Drug experience, N [%] | 4 [57] | 21 [39] | 29 [34] | ||||
| MDMA plasma concentration Cmax, ng/ml | 218 ± 43 (7) | 225 ± 54 (54) | 231 ± 45 (85) | 0.48 | NS | NS | 0.007 |
| MDMA plasma concentration AUC6, ng*h/ml | 894 ± 201 (7) | 945 ± 211 (54) | 972 ± 196 (85) | 0.65 | NS | NS | 0.009 |
| Visual Analog Scale rating ΔEmax | |||||||
| Any drug effect | 66 ± 20 (7) | 69 ± 29 (54) | 75 ± 26 (85) | 0.59 | NS | NS | 0.007 |
| Good drug effect | 69 ± 26 (7) | 72 ± 30 (54) | 74 ± 28 (85) | 0.05 | NS | NS | 0.001 |
| Bad drug effect | -0.7 ± 19 (7) | 18 ± 29 (54) | 16 ± 21 (85) | 1.57 | NS | NS | 0.020 |
| Drug liking | 79 ± 20 (7) | 73 ± 29 (54) | 74 ± 30 (85) | 0.24 | NS | NS | 0.003 |
| Stimulated | 58 ± 33 (7) | 58 ± 35 (54) | 66 ± 34 (85) | 0.70 | NS | NS | 0.009 |
| High mood | 65 ± 27 (7) | 66 ± 36 (54) | 71 ± 31 (85) | 0.19 | NS | NS | 0.003 |
| Concentration | -0.6 ± 5 (7) | 9.2 ± 18 (54) | 8.5 ± 15 (85) | 1.18 | NS | NS | 0.016 |
| Talkative | 15 ± 15 (7) | 20 ± 19 (54) | 22 ± 19 (85) | 0.37 | NS | NS | 0.005 |
| Appetite | -21 ± 29 (3) | -9.8 ± 34 (25) | -4.9 ± 30 (43) | 0.49 | NS | NS | 0.014 |
| Tired | -10 ± 28 (5) | 20 ± 33 (41) | 22 ± 31 (61) | 1.82 | NS | NS | 0.032 |
| Fear | 1.7 ± 2.9 (3) | 4.7 ± 14 (35) | 7.7 ± 18 (58) | 0.48 | NS | NS | 0.010 |
| Happy | 20 ± 16 (4) | 26 ± 19 (42) | 29 ± 19 (57) | 0.28 | NS | NS | 0.005 |
| Want to be hugged | 9.8 ± 20 (4) | 13 ± 19 (29) | 14 ± 18 (42) | 0.05 | NS | NS | 0.001 |
| Want to hug | 8.5 ± 17 (4) | 14 ± 19 (29) | 14 ± 18 (42) | 0.06 | NS | NS | 0.001 |
| Vital signs parameters ΔEmax | |||||||
| Systolic blood pressure, mmHg | 31 ± 7 (7) | 24 ± 12 (54) | 23 ± 14 (85) | 2.00 | NS | NS | 0.026 |
| Diastolic blood pressure, mmHg | 18 ± 6 (7) | 15 ± 11 (54) | 12 ± 8 (85) | 2.99 | 0.05 | NS | 0.038 |
| Mean arterial pressure, mmHg | 23 ± 6 (7) | 18 ± 10 (54) | 16 ± 10 (85) | 3.67 | 0.028* | NS | 0.046 |
| Heat rate beat/min | 16 ± 5 (7) | 19 ± 15 (54) | 17 ± 14 (85) | 0.38 | NS | NS | 0.005 |
| Rate pressure product, mmHg/min | 4,394 ± 1,421 (7) | 4,878 ± 2,775 (54) | 4,264 ± 2,999 (85) | 0.96 | NS | NS | 0.013 |
| Body temperature, °C | 0.6 ± 0.6 (7) | 0.3 ± 0.5 (54) | 0.2 ± 0.5 (85) | 2.59 | 0.08 | NS | 0.035 |
| Adjective Mood Rating Scale rating ΔEmax | |||||||
| Activity | 1.7 ± 3.1 (7) | 2.2 ± 5.9 (54) | 2.4 ± 4.7 (85) | 0.08 | NS | NS | 0.001 |
| High mood | 2.3 ± 1.9 (7) | 2.7 ± 3.3 (54) | 3.0 ± 3.2 (85) | 0.29 | NS | NS | 0.004 |
| Hear/depression | -1.1 ± 2.8 (7) | 1.4 ± 3.2 (54) | 1.2 ± 3.5 (85) | 1.80 | NS | NS | 0.025 |
| DAT1 rs11133767 | CC | CT | TT | F | p value | p valuea | η2 |
| N | 12 | 60 | 77 | ||||
| Female, N [%] | 6 [50] | 29 [48] | 41 [53] | ||||
| Drug experience, N [%] | 5 [42] | 23 [38] | 27 [35] | ||||
| MDMA plasma concentration Cmax, ng/ml | 225 ± 46 (12) | 224 ± 50 (60) | 232 ± 48 (77) | 0.45 | NS | NS | 0.006 |
| MDMA plasma concentration AUC6, ng*h/ml | 933 ± 221 (12) | 947 ± 192 (60) | 973 ± 210 (77) | 0.39 | NS | NS | 0.005 |
| Visual Analog Scale rating ΔEmax | |||||||
| Any drug effect | 68 ± 24 (12) | 70 ± 29 (60) | 76 ± 25 (77) | 0.73 | NS | NS | 0.008 |
| Good drug effect | 70 ± 26 (12) | 71 ± 30 (60) | 74 ± 28 (77) | 0.12 | NS | NS | 0.002 |
| Bad drug effect | 3.9 ± 18 (12) | 17 ± 29 (60) | 17 ± 21 (77) | 1.47 | NS | NS | 0.019 |
| Drug liking | 77 ± 23 (12) | 72 ± 30 (60) | 75 ± 29 (77) | 0.16 | NS | NS | 0.002 |
| Stimulated | 65 ± 29 (12) | 56 ± 36 (60) | 67 ± 33 (77) | 1.37 | NS | NS | 0.017 |
| High mood | 68 ± 28 (12) | 66 ± 36 (60) | 71 ± 31 (77) | 0.16 | NS | NS | 0.002 |
| Concentration | 3.7 ± 10 (12) | 8.4 ± 18 (60) | 9.4 ± 15 (77) | 0.69 | NS | NS | 0.009 |
| Talkative | 22 ± 15 (12) | 19 ± 20 (60) | 22 ± 18 (77) | 0.29 | NS | NS | 0.004 |
| Appetite | -4.1 ± 25 (7) | -13 ± 33 (27) | -3.8 ± 30 (38) | 0.71 | NS | NS | 0.020 |
| Tired | 12 ± 36 (10) | 20 ± 31 (42) | 22 ± 33 (57) | 0.28 | NS | NS | 0.005 |
| Fear | 1.0 ± 1.9 (7) | 4.6 ± 13 (40) | 8.5 ± 19 (50) | 1.09 | NS | NS | 0.023 |
| Happy | 25 ± 15 (7) | 25 ± 20 (45) | 29 ± 19 (54) | 0.36 | NS | NS | 0.007 |
| Want to be hugged | 11 ± 17 (5) | 11 ± 18 (33) | 15 ± 19 (39) | 0.30 | NS | NS | 0.008 |
| Want to hug | 10 ± 15 (5) | 10 ± 17 (33) | 16 ± 18 (39) | 0.70 | NS | NS | 0.017 |
| Vital signs parameters ΔEmax | |||||||
| Systolic blood pressure, mmHg | 29 ± 8 (12) | 24 ± 13 (60) | 23 ± 13 (77) | 1.87 | NS | NS | 0.024 |
| Diastolic blood pressure, mmHg | 17 ± 7 (12) | 14 ± 11 (60) | 12 ± 8 (77) | 2.19 | NS | NS | 0.027 |
| Mean arterial pressure, mmHg | 22 ± 6 (12) | 18 ± 10 (60) | 16 ± 10 (77) | 2.87 | 0.06 | NS | 0.035 |
| Heat rate beat/min | 16 ± 12 (12) | 17 ± 15 (60) | 18 ± 14 (77) | 0.03 | NS | NS | 0.000 |
| Rate pressure product, mmHg/min | 4,592 ± 2,500 (12) | 4,550 ± 2,840 (60) | 4,384 ± 2,950 (77) | 0.14 | NS | NS | 0.002 |
| Body temperature, °C | 0.4 ± 0.6 (12) | 0.2 ± 0.5 (60) | 0.2 ± 0.5 (77) | 1.13 | NS | NS | 0.015 |
| Adjective Mood Rating Scale rating ΔEmax | |||||||
| Activity | 3.3 ± 5.1 (12) | 2.3 ± 5.7 (60) | 2.4 ± 4.6 (77) | 0.23 | NS | NS | 0.003 |
| High mood | 3.7 ± 2.6 (12) | 2.6 ± 3.2 (60) | 2.9 ± 3.2 (77) | 0.66 | NS | NS | 0.009 |
| Fear/depression | -0.8 ± 2 (12) | 1.2 ± 3.3 (60) | 1.4 ± 3.4 (77) | 2.28 | NS | NS | 0.030 |
| DAT1 rs11564774 | CC | CG | GG | F | p value | p valuea | η2 |
| N | 62 | 66 | 20 | ||||
| Female, N [%] | 33 [53] | 35 [53] | 7 [35] | ||||
| Drug experience, N [%] | 22 [35] | 18 [27] | 14 [70] | ||||
| MDMA plasma concentration Cmax, ng/ml | 230 ± 48 (62) | 230 ± 48 (66) | 213 ± 50 (20) | 1.05 | NS | NS | 0.014 |
| MDMA plasma concentration AUC6, ng*h/ml | 965 ± 210 (62) | 977 ± 200 (66) | 876 ± 179 (20) | 1.98 | NS | NS | 0.027 |
| Visual Analog Scale rating ΔEmax | |||||||
| Any drug effect | 75 ± 25 (62) | 69 ± 28 (66) | 74 ± 23 (20) | 1.70 | NS | NS | 0.019 |
| Good drug effect | 74 ± 28 (62) | 70 ± 30 (66) | 77 ± 26 (20) | 1.38 | NS | NS | 0.018 |
| Bad drug effect | 18 ± 23 (62) | 14 ± 25 (66) | 16 ± 29 (20) | 0.73 | NS | NS | 0.009 |
| Drug liking | 74 ± 31 (62) | 72 ± 29 (66) | 82 ± 23 (20) | 1.72 | NS | NS | 0.022 |
| Stimulated | 68 ± 32 (62) | 57 ± 36 (66) | 63 ± 35 (20) | 2.37 | 0.10 | NS | 0.029 |
| High mood | 71 ± 32 (62) | 65 ± 34 (66) | 72 ± 34 (20) | 1.40 | NS | NS | 0.018 |
| Concentration | 9.5 ± 16 (62) | 7.8 ± 16 (66) | 8.6 ± 16 (20) | 0.19 | NS | NS | 0.003 |
| Talkative | 23 ± 19 (62) | 19 ± 19 (66) | 21 ± 17 (20) | 0.61 | NS | NS | 0.008 |
| Appetite | -2.9 ± 29 (32) | -8.6 ± 30 (27) | -15 ± 35 (13) | 1.21 | NS | NS | 0.034 |
| Tired | 25 ± 34 (45) | 19 ± 28 (47) | 10 ± 37 (17) | 1.13 | NS | NS | 0.020 |
| Fear | 8.9 ± 20 (44) | 1.8 ± 4.9 (37) | 11 ± 20 (15) | 2.57 | 0.08 | NS | 0.053 |
| Happy | 27 ± 19 (42) | 26 ± 19 (52) | 30 ± 17 (11) | 0.87 | NS | NS | 0.016 |
| Want to be hugged | 10 ± 16 (30) | 15 ± 19 (39) | 14 ± 22 (7) | 0.44 | NS | NS | 0.011 |
| Want to hug | 11 ± 16 (30) | 15 ± 18 (39) | 14 ± 22 (7) | 0.38 | NS | NS | 0.010 |
| Vital signs parameters ΔEmax | |||||||
| Systolic blood pressure, mmHg | 22 ± 13 (62) | 25 ± 13 (66) | 23 ± 12 (20) | 1.43 | NS | NS | 0.018 |
| Diastolic blood pressure, mmHg | 12 ± 8 (62) | 14 ± 9 (66) | 15 ± 12 (20) | 1.83 | NS | NS | 0.023 |
| Mean arterial pressure, mmHg | 16 ± 9 (62) | 18 ± 9 (66) | 19 ± 11 (20) | 1.86 | NS | NS | 0.023 |
| Heat rate beat/min | 17 ± 15 (62) | 18 ± 15 (66) | 18 ± 12 (20) | 0.05 | NS | NS | 0.001 |
| Rate pressure product, mmHg/min | 4,337 ± 3,024 (62) | 4,600 ± 2,817 (66) | 4,551 ± 2,573 (20) | 0.23 | NS | NS | 0.003 |
| Body temperature, °C | 0.2 ± 0.5 (62) | 0.3 ± 0.5 (66) | 0.3 ± 0.5 (20) | 0.72 | NS | NS | 0.010 |
| Adjective Mood Rating Scale rating ΔEmax | |||||||
| Activity | 3.2 ± 4.9 (62) | 2 ± 5.7 (66) | 1.4 ± 2.9 (20) | 1.23 | NS | NS | 0.017 |
| High mood | 3.1 ± 3.3 (62) | 2.7 ± 3.3 (66) | 2.4 ± 2.1 (20) | 0.42 | NS | NS | 0.006 |
| Fear/depression | 1.0 ± 3.6 (62) | 1.4 ± 3.3 (66) | 0.6 ± 2 (20) | 0.42 | NS | NS | 0.006 |
| DAT1 rs460000 | GG | GT | TT | F | p value | p valuea | η2 |
| N | 81 | 58 | 10 | ||||
| Female, N [%] | 43 [53] | 32 [55] | 1 [10] | ||||
| Drug experience, N [%] | 31 [38] | 17 [29] | 7 [70] | ||||
| MDMA plasma concentration Cmax, ng/ml | 230 ± 49 (81) | 230 ± 49 (58) | 199 ± 35 (10) | 1.96 | NS | NS | 0.026 |
| MDMA plasma concentration AUC6, ng*h/ml | 967 ± 211 (81) | 967 ± 196 (58) | 851 ± 155 (10) | 1.55 | NS | NS | 0.021 |
| Visual Analog Scale rating ΔEmax | |||||||
| Any drug effect | 72 ± 27 (81) | 73 ± 27 (58) | 74 ± 23 (10) | 0.60 | NS | NS | 0.007 |
| Good drug effect | 71 ± 29 (81) | 75 ± 28 (58) | 75 ± 27 (10) | 0.59 | NS | NS | 0.007 |
| Bad drug effect | 17 ± 22 (81) | 16 ± 26 (58) | 13 ± 36 (10) | 0.03 | NS | NS | 0.000 |
| Drug liking | 71 ± 31 (81) | 77 ± 27 (58) | 78 ± 21 (10) | 0.95 | NS | NS | 0.012 |
| Stimulated | 64 ± 34 (81) | 62 ± 36 (58) | 51 ± 30 (10) | 0.29 | NS | NS | 0.004 |
| High mood | 69 ± 32 (81) | 68 ± 35 (58) | 73 ± 29 (10) | 0.40 | NS | NS | 0.005 |
| Concentration | 9.0 ± 15 (81) | 7.4 ± 16 (58) | 11 ± 20 (10) | 0.29 | NS | NS | 0.004 |
| Talkative | 23 ± 19 (81) | 19 ± 19 (58) | 20 ± 11 (10) | 0.55 | NS | NS | 0.007 |
| Appetite | -4.8 ± 28 (36) | -6.4 ± 34 (29) | -24 ± 27 (7) | 1.51 | NS | NS | 0.041 |
| Tired | 24 ± 33 (54) | 16 ± 31 (46) | 12 ± 29 (9) | 1.00 | NS | NS | 0.018 |
| Fear | 8 ± 19 (55) | 2.5 ± 5.8 (35) | 13 ± 25 (7) | 1.86 | NS | NS | 0.038 |
| Happy | 27 ± 18 (60) | 28 ± 20 (41) | 21 ± 14 (5) | 0.05 | NS | NS | 0.001 |
| Want to be hugged | 10 ± 16 (45) | 19 ± 21 (29) | 0 ± 0 (3) | 2.36 | NS | NS | 0.056 |
| Want to hug | 11 ± 16 (45) | 19 ± 20 (29) | 0 ± 0 (3) | 2.26 | NS | NS | 0.053 |
| Vital signs parameters ΔEmax | |||||||
| Systolic blood pressure, mmHg | 23 ± 14 (81) | 25 ± 11 (58) | 24 ± 12 (10) | 0.49 | NS | NS | 0.006 |
| Diastolic blood pressure, mmHg | 13 ± 9 (81) | 14 ± 8 (58) | 18 ± 17 (10) | 2.97 | 0.05 | NS | 0.037 |
| Mean arterial pressure, mmHg | 16 ± 10 (81) | 18 ± 8 (58) | 22 ± 13 (10) | 2.90 | 0.06 | NS | 0.036 |
| Heat rate beat/min | 16 ± 15 (81) | 19 ± 15 (58) | 16 ± 7 (10) | 0.66 | NS | NS | 0.009 |
| Rate pressure product, mmHg/min | 4,219 ± 2,944 (81) | 4,902 ± 2,877 (58) | 3,963 ± 1,624 (10) | 1.03 | NS | NS | 0.013 |
| Body temperature, °C | 0.2 ± 0.5 (81) | 0.3 ± 0.4 (58) | 0.3 ± 0.6 (10) | 0.73 | NS | NS | 0.010 |
| Adjective Mood Rating Scale rating ΔEmax | |||||||
| Activity | 2.5 ± 5.2 (81) | 2.4 ± 5.3 (58) | 2.0 ± 2.7 (10) | 0.02 | NS | NS | 0.000 |
| High mood | 2.8 ± 3.3 (81) | 3.0 ± 3.2 (58) | 2.2 ± 1.3 (10) | 0.26 | NS | NS | 0.004 |
| Fear/depression | 0.9 ± 3 (81) | 1.4 ± 3.7 (58) | 1.2 ± 1.5 (10) | 0.46 | NS | NS | 0.006 |
| DAT1 rs463379 | CC | CG | GG | F | p value | p valuea | η2 |
| N | 94 | 48 | 7 | ||||
| Female, N [%] | 52 [55] | 22 [46] | 2 [29] | ||||
| Drug experience, N [%] | 33 [35] | 20 [42] | 2 [29] | ||||
| MDMA plasma concentration Cmax, ng/ml | 232 ± 50 (94) | 221 ± 47 (48) | 221 ± 37 (7) | 0.98 | NS | NS | 0.013 |
| MDMA plasma concentration AUC6, ng*h/ml | 971 ± 200 (94) | 937 ± 214 (48) | 958 ± 185 (7) | 0.46 | NS | NS | 0.006 |
| Visual Analog Scale rating ΔEmax | |||||||
| Any drug effect | 73 ± 26 (94) | 71 ± 28 (48) | 72 ± 20 (7) | 0.01 | NS | NS | 0.000 |
| Good drug effect | 75 ± 28 (94) | 69 ± 31 (48) | 67 ± 26 (7) | 0.68 | NS | NS | 0.009 |
| Bad drug effect | 18 ± 26 (94) | 14 ± 21 (48) | 9.1 ± 17 (7) | 0.57 | NS | NS | 0.007 |
| Drug liking | 77 ± 27 (94) | 69 ± 33 (48) | 65 ± 27 (7) | 1.27 | NS | NS | 0.016 |
| Stimulated | 61 ± 35 (94) | 66 ± 33 (48) | 57 ± 37 (7) | 0.71 | NS | NS | 0.009 |
| High mood | 70 ± 33 (94) | 67 ± 32 (48) | 64 ± 33 (7) | 0.14 | NS | NS | 0.002 |
| Concentration | 9.1 ± 17 (94) | 7.9 ± 15 (48) | 5.4 ± 11 (7) | 0.23 | NS | NS | 0.003 |
| Talkative | 23 ± 19 (94) | 18 ± 18 (48) | 17 ± 20 (7) | 0.86 | NS | NS | 0.011 |
| Appetite | -6.8 ± 33 (53) | -6.7 ± 26 (15) | -15 ± 16 (4) | 0.11 | NS | NS | 0.003 |
| Tired | 19 ± 32 (72) | 22 ± 34 (32) | 19 ± 23 (5) | 0.23 | NS | NS | 0.004 |
| Fear | 6.4 ± 18 (66) | 5 ± 9.5 (27) | 14 ± 10 (4) | 0.56 | NS | NS | 0.012 |
| Happy | 28 ± 19 (65) | 25 ± 19 (38) | 24 ± 25 (3) | 0.32 | NS | NS | 0.006 |
| Want to be hugged | 16 ± 20 (41) | 8.6 ± 15 (33) | 20 ± 26 (3) | 1.85 | NS | NS | 0.044 |
| Want to hug | 16 ± 19 (41) | 8.8 ± 14 (33) | 22 ± 26 (3) | 2.12 | NS | NS | 0.050 |
| Vital signs parameters ΔEmax | |||||||
| Systolic blood pressure, mmHg | 23 ± 13 (94) | 24 ± 13 (48) | 26 ± 15 (7) | 0.35 | NS | NS | 0.005 |
| Diastolic blood pressure, mmHg | 14 ± 10 (94) | 13 ± 9 (48) | 12 ± 6 (7) | 0.16 | NS | NS | 0.002 |
| Mean arterial pressure, mmHg | 17 ± 10 (94) | 17 ± 9 (48) | 16 ± 7 (7) | 0.11 | NS | NS | 0.001 |
| Heat rate beat/min | 17 ± 14 (94) | 17 ± 13 (48) | 22 ± 21 (7) | 0.32 | NS | NS | 0.004 |
| Rate pressure product, mmHg/min | 4,500 ± 2,891 (94) | 4,239 ± 2,512 (48) | 5,607 ± 4,506 (7) | 0.66 | NS | NS | 0.009 |
| Body temperature, °C | 0.2 ± 0.5 (94) | 0.3 ± 0.5 (48) | 0.2 ± 0.6 (7) | 0.84 | NS | NS | 0.011 |
| Adjective Mood Rating Scale rating ΔEmax | |||||||
| Activity | 2.4 ± 5.7 (94) | 2.1 ± 4.0 (48) | 4.0 ± 2.4 (7) | 0.42 | NS | NS | 0.006 |
| High mood | 3 ± 3.1 (94) | 2.5 ± 3.3 (48) | 3.7 ± 3.5 (7) | 0.63 | NS | NS | 0.009 |
| Fear/depression | 1.2 ± 3.2 (94) | 1.4 ± 3.6 (48) | -1.4 ± 3.6 (7) | 2.25 | NS | NS | 0.030 |
| N | 7 | 47 | 93 | ||||
| Female, N [%] | 2 [29] | 21 [45] | 51 [55] | ||||
| Drug experience, N [%] | 2 [29] | 20 [43] | 32 [34] | ||||
| MDMA plasma concentration Cmax, ng/ml | 221 ± 37 (7) | 221 ± 47 (47) | 232 ± 50 (93) | 0.86 | NS | NS | 0.012 |
| MDMA plasma concentration AUC6, ng*h/ml | 958 ± 185 (7) | 934 ± 215 (47) | 970 ± 200 (93) | 0.49 | NS | NS | 0.007 |
| Visual Analog Scale rating ΔEmax | |||||||
| Any drug effect | 72 ± 20 (7) | 71 ± 28 (47) | 73 ± 26 (93) | 0.00 | NS | NS | 0.000 |
| Good drug effect | 67 ± 26 (7) | 69 ± 31 (47) | 75 ± 28 (93) | 0.60 | NS | NS | 0.008 |
| Bad drug effect | 9.1 ± 17 (7) | 13 ± 21 (47) | 18 ± 27 (93) | 0.62 | NS | NS | 0.008 |
| Drug liking | 65 ± 27 (7) | 69 ± 33 (47) | 77 ± 27 (93) | 1.19 | NS | NS | 0.016 |
| Stimulated | 57 ± 37 (7) | 65 ± 33 (47) | 61 ± 35 (93) | 0.68 | NS | NS | 0.009 |
| High mood | 64 ± 33 (7) | 67 ± 32 (47) | 70 ± 33 (93) | 0.10 | NS | NS | 0.001 |
| Concentration | 5.4 ± 11 (7) | 8.1 ± 15 (47) | 9.2 ± 17 (93) | 0.23 | NS | NS | 0.003 |
| Talkative | 17 ± 20 (7) | 19 ± 18 (47) | 23 ± 19 (93) | 0.64 | NS | NS | 0.009 |
| Appetite | -15 ± 16 (4) | -6.7 ± 26 (15) | -6.8 ± 33 (53) | 0.11 | NS | NS | 0.003 |
| Tired | 19 ± 23 (5) | 22 ± 34 (32) | 19 ± 32 (72) | 0.23 | NS | NS | 0.004 |
| Fear | 14 ± 10 (4) | 5 ± 9.5 (27) | 6.4 ± 18 (66) | 0.56 | NS | NS | 0.012 |
| Happy | 24 ± 25 (3) | 25 ± 19 (37) | 28 ± 18 (64) | 0.23 | NS | NS | 0.004 |
| Want to be hugged | 20 ± 26 (3) | 7.7 ± 14 (32) | 15 ± 19 (40) | 2.02 | NS | NS | 0.050 |
| Want to hug | 22 ± 26 (3) | 8.1 ± 14 (32) | 15 ± 19 (40) | 2.22 | NS | NS | 0.054 |
| Vital signs parameters ΔEmax | |||||||
| Systolic blood pressure, mmHg | 26 ± 15 (7) | 24 ± 14 (47) | 23 ± 13 (93) | 0.27 | NS | NS | 0.004 |
| Diastolic blood pressure, mmHg | 12 ± 6 (7) | 13 ± 9 (47) | 14 ± 10 (93) | 0.15 | NS | NS | 0.002 |
| Mean arterial pressure, mmHg | 16 ± 7 (7) | 17 ± 9 (47) | 17 ± 10 (93) | 0.09 | NS | NS | 0.001 |
| Heat rate beat/min | 22 ± 21 (7) | 17 ± 13 (47) | 17 ± 14 (93) | 0.30 | NS | NS | 0.004 |
| Rate pressure product, mmHg/min | 5,607 ± 4,506 (7) | 4,245 ± 2,539 (47) | 4,514 ± 2,903 (93) | 0.64 | NS | NS | 0.009 |
| Body temperature, °C | 0.2 ± 0.6 (7) | 0.3 ± 0.5 (47) | 0.2 ± 0.5 (93) | 0.67 | NS | NS | 0.009 |
| Adjective Mood Rating Scale rating ΔEmax | |||||||
| Activity | 4.0 ± 2.4 (7) | 2.1 ± 4.1 (47) | 2.4 ± 5.7 (93) | 0.41 | NS | NS | 0.006 |
| High mood | 3.7 ± 3.5 (7) | 2.5 ± 3.3 (47) | 2.9 ± 3.1 (93) | 0.57 | NS | NS | 0.008 |
| Fear/depression | -1.4 ± 3.6 (7) | 1.4 ± 3.6 (47) | 1.2 ± 3.2 (93) | 2.27 | NS | NS | 0.031 |
N, number of subjects; SD, standard deviation; NS, not significant; Δ, values are change scores from placebo; ap value additionally corrected for multiple comparisons according to the Nyholt method; η2, eta square; *, uncorrected p < 0.05.