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Cumulative urinary drug recovery of pyragrel and four major metabolites (normalized to pyragrel) within 24 h after single dose of pyragrel 60, 120, or 240 mg (n=12; Mean ± SD %).
| 60 mg | 120 mg | 240 mg | |
|---|---|---|---|
| Pyragrel | 0.94 ± 0.30 | 0.67 ± 0.14 | 0.79 ± 0.28 |
| BJS | 69.21 ± 10.59 | 66.99 ± 6.18 | 69.13 ± 8.39 |
| BBS | 3.90 ± 2.11 | 1.93 ± 0.85 | 2.75 ± 0.97 |
| MW328 | 0.23 ± 0.33 | 1.16 ± 1.76 | 0.37 ± 0.58 |
| MW318 | 0.44 ± 0.34 | 0.67 ± 0.25 | 0.44 ± 0.24 |
| Total | 74.66 ± 11.58 | 70.73 ± 6.76 | 73.28 ± 8.78 |
