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. 2019 Oct 30;9:15582. doi: 10.1038/s41598-019-52103-x

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Liraglutide and GUB09-145 improve metabolic parameters in DIO mice. (A) Absolute body weight (g), (B) Body weight gain (%) relative to treatment start; (C) Daily food intake (g); (D) Cumulative energy intake (kcal/day); (E) Oral glucose tolerance test (OGTT) on treatment day 27, (F) Glucose area-under the-curve (glucose AUC_{0-240 min}); (G) Fasting blood glucose concentrations (mmol/L) on treatment day 14; (H) Fasting plasma insulin levels (pg/ml) on treatment day 28; (I) Plasma total triglycerides (TG, mmol/L) on treatment day 28; (J) Plasma total cholesterol (TC, mmol/L) on treatment day 28. *p < 0.05, **p < 0.01, ***p < 0.001 compared to DIO vehicle controls.