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. 2019 Oct 30;9:15641. doi: 10.1038/s41598-019-52253-y

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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BBR increases Trib1 mRNA levels and reduces circulating serum lipid levels in hyperlipidemic mice. Mice fed a HFHCD diet were treated with BBR (200 mg/kg, n = 10) or with vehicle (n = 10) for 14 days. At the end of drug treatment all the mice were sacrificed for serum and liver tissue collection. (A–C) LDL-C, TC and TG levels in mice sera were measured after the treatment with BBR or the vehicle. (D) Liver index was measured in BBR or the vehicle treated mice. (E–F) Liver TG and TC contents were measured in individual liver sample treated with BBR or the vehicle. (G) Quantitative real-time PCR were used to determine the relative expression levels of Trib1 and other hepatic genes after normalization with Gapdh mRNA levels. Values are the mean ± S.E.M. of 10 samples per group. *P < 0.05, **P < 0.01, and ***P < 0.001, compared with the vehicle control group.