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. 2019 Oct 30;9:15641. doi: 10.1038/s41598-019-52253-y

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Induction of TRIB1 gene expression and downregulation of lipogenic genes by BBR in human liver cells. (A) HepG2 cells were seeded in 12-well cell culture plate (5 × 10⁵cell/well) and treated with BBR (40 μM) in duplicate wells for different time intervals as indicated. Total RNA was isolated from treated cells for real-time PCR analysis. The data shown are mean ± S.E.M. of two RNA samples with triplicate measurement per RNA sample. (B) HPHs were treated with BBR (20 μM) or DMSO for 3 h in triplicate wells. TRIB1 mRNA levels were determined by real-time PCR. The data shown are mean ± S.E.M. of three RNA samples with triplicate measurements per RNA sample. *P < 0.05, **P < 0.01, and ***P < 0.001, compared with DMSO control.