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. 2019 Oct 24;10:1283. doi: 10.3389/fphar.2019.01283

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Copyright © 2019 Qian, Deng, Liang, Pang, Wu, Yang, Zhou and Yu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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8-Formylophiopogonanone B (8-FOB) suppresses paraquat (PQ)-induced cytotoxicity in L02 cells. (A) Fitted curve showing the inhibition of cytotoxicity by 8-FOB. The EC50 value of 8-FOB for the protection against PQ toxicity in L02 cells was 8.057 μM. (B) The effect of pretreatment with different 8-FOB concentrations on cell viability in the presence of 500 μM PQ. The values are presented as the means ± SEM (n = 6). *p < 0.05, **p < 0.01 vs control group; ^# p < 0.05, ^## p < 0.01 vs the PQ group. (C) Representative images showing the effects of 8-FOB pretreatment on cell damage induced by 500 μM PQ. Scale bar: 80 μm.