Table 5.
Fine and Gray (Competing Risks) Models of Outcomes Time to Discharge Alive and Time to Mortality (N = 248)
| Model 1 | Model 2 | Model 3 | ||||
|---|---|---|---|---|---|---|
| Outcome Event = Discharge Alive (Competing Event = Mortality) |
sHR (95% CI) | P value | asHR (95% CI) | P value | asHR (95% CI) | P value |
| Early ID consult (reference = standard care) | 1.51 (1.11–2.03) | .008 | 1.58 (1.11–2.23) | .01 | 1.57 (1.11–2.24) | .01 |
| Age at index date | 0.99 (0.97–1.00) | .008 | 0.99 (0.97–1.00) | .01 | ||
| Race/ethnicity (reference = Non-Hispanic white) | ||||||
| Hispanic | 0.86 (0.56–1.32) | .48 | 0.88 (0.57–1.36) | .57 | ||
| Non-Hispanic black | 0.85 (0.54–1.35) | .49 | 0.85 (0.54–1.36) | .50 | ||
| Other/unknown | 1.03 (0.60–1.74) | .92 | 1.09 (0.65–1.82) | .75 | ||
| Charlson comorbidity score | 0.96 (0.90–1.02) | .21 | ||||
| Hemiplegia or paraplegia (reference = no) | 1.20 (0.61–2.35) | .60 | ||||
| Recent hospital admission (reference = no) | 0.97 (0.64–1.47) | 0.90 | 0.88 (0.60–1.29) | .51 | ||
| Recent IV antibiotics (reference = no) | 0.99 (0.66–1.49) | 0.96 | 0.97 (0.64–1.47) | .89 | ||
| History of MDRO (reference = no) | 0.95 (0.61–1.46) | 0.81 | 0.92 (0.60–1.42) | .70 | ||
| Hypotension (reference = no) | 1.24 (0.84–1.81) | 0.28 | 1.17 (0.80–1.72) | .41 | ||
| Lactate ≥4 (reference = no) | 1.02 (0.72–1.43) | 0.92 | 1.01 (0.72–1.42) | .95 | ||
| Vasopressors (reference = no) | 0.48 (0.33–0.70) | 0.0001 | 0.50 (0.35–0.72) | .0002 | ||
| Mechanical ventilation (reference = no) | 0.70 (0.44–1.12) | 0.13 | 0.71 (0.44–1.14) | .15 | ||
| Intra-abdominal source of infection (reference = no) | 1.27 (0.78–2.06) | 0.34 | 1.30 (0.80–2.13) | .29 | ||
| Outcome Event = Mortality (Competing Event = Discharge Alive) |
||||||
| Early ID consult (reference = standard care) | 0.61 (0.39–0.98) | 0.04 | 0.60 (0.36–1.00) | 0.0497 | 0.61 (0.37–1.02) | .06 |
| Age at index date | 1.02 (1.00–1.04) | 0.02 | 1.02 (1.00–1.04) | .02 | ||
| Race/ethnicity (reference = Non-Hispanic white) | ||||||
| Hispanic | 1.33 (0.75–2.37) | 0.33 | 1.32 (0.73–2.35) | .36 | ||
| Non-Hispanic black | 0.88 (0.44–1.74) | 0.71 | 0.92 (0.46–1.82) | .81 | ||
| Other/unknown | 0.90 (0.37–2.17) | 0.81 | 0.88 (0.36–2.14) | .78 | ||
| Charlson comorbidity score | 1.02 (0.95–1.10) | 0.54 | ||||
| Hemiplegia or paraplegia (reference = no) | 0.57 (0.15–2.14) | .41 | ||||
| Recent hospital admission (reference = no) | 1.10 (0.61–2.00) | 0.75 | 1.15 (0.64–2.08) | .64 | ||
| Recent IV antibiotics (reference = no) | 1.16 (0.61–2.20) | 0.65 | 1.20 (0.63–2.29) | .57 | ||
| History of MDRO (reference = no) | 1.12 (0.60–2.08) | 0.73 | 1.12 (0.60–2.10) | .71 | ||
| Hypotension (reference = no) | 0.79 (0.45–1.37) | 0.39 | 0.81 (0.47–1.41) | .46 | ||
| Lactate ≥4 (reference = no) | 1.06 (0.65–1.72) | 0.83 | 1.04 (0.64–1.71) | .87 | ||
| Vasopressors (reference = no) | 2.26 (1.35–3.76) | 0.002 | 2.28 (1.38–3.79) | .001 | ||
| Mechanical ventilation (reference = no) | 1.68 (0.94–3.01) | 0.08 | 1.67 (0.94–2.98) | .08 | ||
| Intra-abdominal source of infection (reference = no) | 0.63 (0.29–1.39) | 0.26 | 0.62 (0.28–1.38) | .24 |
Bold values indicate those that are statistically significant.
Abbreviations: asHR, adjusted subdistribution hazard ratio; CI, confidence interval; ID, infectious diseases; IV, intravenous; MDRO, multidrug-resistant organism; subdistribution hazard ratio, sHR.