TABLE 3.
MICs of antimicrobials for the CTX-M-64-producing E. coli strain B22 and CTX-M-123-producing E. coli B64 strain and its transconjugants
| Antimicrobial | MIC (mg/liter) |
||||
|---|---|---|---|---|---|
| B22 (blaCTX-M-64) | B64 (blaCTX-M-123) | χ1037 Rifr transconjugant (blaCTX-M-123/pB64) | χ1037 Rifr transconjugantb (blaCTX-M-64/pUIH-1) | χ1037 Rifr | |
| Piperacillin | >64 | >64 | >64 | >64 | ≤0.25 |
| SAMc | 8/16 | 8/16 | 8/16 | 8/16 | ≤2/4 |
| Cefazolin | >16 | >16 | >16 | >16 | 1 |
| Cefotiam | >16 | >16 | >16 | >16 | ≤0.25 |
| Cefotaximea | >2,048 | 2,048 | 2,048 | >2,048 | ≤0.25 |
| Ceftazidimea | 64 | 32 | 32 | 64 | ≤0.25 |
| Cefpodoxime | >4 | >4 | >4 | >4 | ≤1 |
| Cefepime | 8 | >16 | >16 | >16 | ≤0.25 |
| Flomoxef | ≤0.5 | 16 | ≤0.5 | ≤0.5 | ≤0.5 |
| Aztreonam | >16 | >16 | 16 | >16 | ≤0.5 |
| Imipenem | ≤0.25 | ≤0.25 | ≤0.25 | ≤0.25 | ≤0.25 |
| Meropenem | ≤0.25 | ≤0.25 | ≤0.25 | ≤0.25 | ≤0.25 |
| Gentamicin | ≤0.25 | 0.5 | ≤0.25 | 1 | ≤0.25 |
| Amikacin | 4 | 4 | ≤1 | 2 | ≤1 |
| Minocycline | 4 | 0.5 | 1 | 1 | 1 |
| Levofloxacin | >4 | ≤0.25 | ≤0.25 | ≤0.25 | ≤0.25 |
| Fosfomycin | ≤32 | ≤32 | ≤32 | ≤32 | ≤32 |
| SXTc | ≤9.5/0.5 | ≤9.5/0.5 | ≤9.5/0.5 | ≤9.5/0.5 | ≤9.5/0.5 |
a
The antibiotic-containing plates were prepared in-house.
b
As described by Nagano et al. (12).
c
SAM, ampicillin-sulbactam; SXT, trimethoprim-sulfamethoxazole.