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. 2019 Sep 19;3(4):311–330. doi: 10.7150/ntno.38954

Figure 7.

Figure 7

Dual-targeting efficient of the dual-functionalized dendrimer evaluated in vivo using glioma-bearing CB-17 SCID mice as model. (a) Dual-targeting effect detected by in vivo imaging system after accumulating for 6 h, 12 h, 24 h and 48 h. The glioma-bearing mice were administrated with Cy5.5-labeled dendrimers at a Cy5.5 dose of 2 mg/kg. (b) Glioma-targeting effect of the dual-targeting dendrimer through observing the accumulated Cy5.5-labeled dendrimer in the excised brains at 24 h after administrating. (c) Dual-targeting efficacy was evaluated by calculating the fluorescent intensity accumulated in the brain of the glioma-bearing mice by LiveImaging software.