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| Biological Agent | Action |
|---|---|
| Adalimumab, certolizumab pegol, etanercept, golimumab, infliximab | Tumor necrosis factor inhibition |
| Anakinra | Interleukin-1 receptor antagonism |
| Abatacept | T cell costimulation inhibition (anti CD80/86) |
| Sarilumab, tocilizumab | Interleukin-6 receptor antagonism |
| Ustekinumab | The p40 subunit of interleukin-12/23 inhibition |
| Ixekizumab, secukinumab | Interleukin-17 inhibition |
| Rituximab | B-cell depletion (anti-CD20) |
