Figure 1.

Schedule of CSDS, treatment, and brain collection. CSDS was performed from Day 1 to Day 10. A social interaction test was performed on Day 11 to select susceptible mice. On Day 12, saline (10 ml/kg) or (R)-ketamine (10 mg/kg) was administered i.p. to susceptible mice. Saline (10 ml/kg) was also administered i.p. to control (no CSDS) mice. Golgi-Cox staining in the control mice and CSDS-susceptible mice was performed 3 hours after a single administration of saline or (R)-ketamine. Abbreviations: CSDS, chronic social defeat stress; D, day; i.p., intraperitoneal.