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The effects of NBQX on (R)-ketamine- and (S)-ketamine-induced monoamine release in the prefrontal cortex (PFC) of mice. (R)-Ketamine (20 mg/kg) (A) or (S)-ketamine (20 mg/kg) (B) was i.p. injected at 0 minutes (solid arrow). NBQX (10 mg/kg) or vehicle was s.c. injected 20 minutes before ketamine treatment (dotted arrow). Results are expressed as the mean ± SEM of 5 mice per group. *P < .05, **P < .01, compared with vehicle-pretreated mice at each time point.
