Figure 4.

The effects of local application of (R)-ketamine and (S)-ketamine on extracellular monoamine levels in the prefrontal cortex (PFC) of mice. (R)-Ketamine (50 µM), (S)-ketamine (50 µM), or vehicle was perfused into the PFC via the dialysis probe for the time indicated by the horizontal bar. Results are expressed as the mean ± SEM of 5 mice per group. *P < .05, ^**P < .01, compared with the vehicle-treated mice at each time point. ^#P < .05, ^##P < .01, compared with the (S)-ketamine-treated mice at each time point.