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. 2019 Jul 5;28:48–57. doi: 10.1016/j.molmet.2019.07.004

Figure 2.

Figure 2

Tbx15 adipose-specific knockout impairs cold-induced adipocyte thermogenesis and browning. A-B. Representative H&E staining of brown adipose tissue (BAT, A) and inguinal white adipose tissue (IngWAT, B) from mice at room temperature (RT, upper panel) or following cold exposure (4 °C, lower panel). C-D. Western blot analysis of UCP1 in BAT (C) and IngWAT (D) normalized to GAPDH. E. Volcano map analysis of IngWAT RNA-seq data in separate cohorts of AKO and control mice after 24 h cold exposure. F. qPCR analysis of thermogenic and beige selective gene expression in inguinal adipose tissue from control and AKO mice following cold exposure at 4 °C for 24 h (n = 5). Data represent mean ± SEM, *p < 0.05.